Immunomodulating effects of Phlebotomine saliva in Leishmania infection: Review

Ivan Brito Feitosa, Wesley Roberto de Aguida, Carolina Bioni Garcia Teles


Abstract. The recognized action of some proteins present in the saliva of the phlebotomine dipteran vectors of Leishmaniasis, as modulators of the hemostatic, inflammatory and immune responses during the colonization of the protozoan in the host organism, created the expectation of formulating a vaccine against this disease. The present study aimed to provide an overview about researchs that deals with the role of phlebotomine saliva in Leishmania infections. A bibliographic search was carried out in PubMed, SciELO and LILACS databases. The articles listed address the following aspects of the vector’s saliva: intensification of infection; suppression and modulation of the host immune system; chemotaxis on phagocytic cells; induction of innate and adaptive immunity; isolation and characterization of immunoactive molecules and their possible protective function against Leishmaniasis.

Efeitos imunomoduladores da saliva de flebotomínio na infecção por Leishmania: Revisão

Resumo. A reconhecida ação de algumas proteínas presentes na saliva dos vetores flebotomíneos da Leishmaniose, como moduladores das respostas hemostáticas, inflamatórias e imunes durante a colonização do protozoário no organismo hospedeiro, criou a expectativa de formular uma vacina contra essa doença. O presente estudo teve como objetivo fornecer uma visão geral sobre pesquisas que abordam o papel da saliva de flebotomíneos em infecções por Leishmania. Foi realizada uma pesquisa bibliográfica nas bases de dados PubMed, SciELO e LILACS. Os artigos listados abordam os seguintes aspectos da saliva do vetor: intensificação da infecção; supressão e modulação do sistema imune do hospedeiro; quimiotaxia em células fagociticas; indução da imunidade inata e adaptativa; isolamento e caracterização de moléculas imunoativas e sua possível função protetora contra a leishmaniose.


Leishmania; Lutzomyia; Phlebotomus; sandflies; saliva; protection; flebótomos; saliva; proteção

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